
Oral Care
Toothpaste, mouthwash and oral sprays use WS-23 for a clean cooling finish without overpowering mint when combined with other flavors.

Cooling Agent WS-23 is a synthetic coolant (N,2,3-trimethyl-2-isopropylbutyramide) supplied as white crystal powder at ≥99% on the supplier sheet, CAS 51115-67-4.
It triggers cold-sensitive receptors without the dominant mint flavor of menthol—positioned as nearly odorless and flavorless icy cooling for formulations that cannot tolerate peppermint character. WS-23 is not interchangeable with WS-3, WS-5, WS-12 or menthol on the same dose line; onset, duration and aroma differ by chemotype.
Supplier literature cites thermal stability to about 200 °C and typical use levels around 30–100 ppm, which matters for baked goods, hot-fill beverages and heat-processed cosmetics. Confirm FEMA/EINECS status for your market on the lot paperwork.
Certificate lines on the trade sheet should be verified on the batch COA—do not assume every logo applies to every shipment.
| Product Name | Cooling Agent WS-23 Powder | Source | Synthetic coolant (N,2,3-trimethyl-2-isopropylbutyramide) |
|---|---|---|---|
| Chemical Name | N, 2, 3-Trimethyl-2-isopropyl Butanamide | Purity / Specification | ≥99% |
| Appearance | White crystal powder | Odor | Mild cooling, slight menthol odor (almost odorless) |
| Solubility | Soluble in ethanol and other organic solvents; slightly soluble in water (7 g/L at 20 °C) | Application | Cosmetics, food, beverage, medicine, tobacco and vape products |
| Grade | Food grade | MOQ | 1 kg |
| CAS No. | 51115-67-4 | Cooling Profile | Long-lasting cooling; low use level (typ. 30–100 ppm); heat stable to ~200 °C per supplier sheet |
| Certificate | ISO 22000, FDA, BRC, COSMOS, IFS, SGS, Kosher, Halal, Organic (EU), USDA, HACCP, ISO 9001 | Quality | Non-GMO, Non-irradiation, Allergen Free, BSE/TSE Free |
| Sample | 10–50 g sample available | OEM Service | Private label and customized packaging |
| Packaging | 1–5 kg / 25 kg (aluminum foil bag, carton or drum) | Shelf Life | 2 years |
| COA | Available |

Toothpaste, mouthwash and oral sprays use WS-23 for a clean cooling finish without overpowering mint when combined with other flavors.

Confectionery, chocolate, dairy, beer, spirits, beverages and chewing gum—pre-dissolve in ethanol or compatible solvent before heat steps if the process exceeds supplier stability guidance.

Skin creams, shaving foam, sunscreen and shower gel for topical cooling; quote food/cosmetic grade on the PO to match your safety file.

Common in vape liquids for smooth throat cooling; fix WS-23 assay and solvent system separately from menthol-based flavors.

Linctus, anti-itch ointments, oral analgesics and similar OTC formats where long cooling duration is desired at low ppm.
Supplier comparison tables rank overall cooling intensity roughly as WS-5 > WS-12 > WS-3 > WS-23, with different aroma and mouthfeel profiles: WS-23 with mild mint burst, WS-3 slower back-of-mouth cooling, WS-12 longer peppermint-leaning duration, WS-5 highest activity across oral mucosa.
Quote the exact agent on the purchase order—do not substitute by “cooling agent” alone when a formula was built around one chemotype.